The Science Center is dedicated to helping innovators and entrepreneurs bring world-changing technologies to market. It is our vision to fuel and support discoveries that solve problems for the entire world, inspire and connect the next generation of scientists, and establish Philadelphia as a global innovation city.

Change Tomorrow
Located in the heart of uCity Square, the Science Center is a mission-driven nonprofit that connects scientists, innovators and entrepreneurs to the capital, talent, and resources needed for any stage of the business lifecycle.
Located in the heart of uCity Square, the Science Center is a mission-driven nonprofit that connects scientists, innovators and entrepreneurs to the capital, talent, and resources needed for any stage of the business lifecycle.

Annual Message

Annual Message Annual Message Annual Message Annual Message Annual Message
view of Center City Philadelphia from the Science Center
Soaring views of 3675 Market Street and the Center City skyline from uCity Square.

Letter from the Chairman and the Interim President

Change is a constant in the world of innovation. And just like the entrepreneurs and innovators the Science Center supports, we are constantly pivoting. Throughout the transitions of the past year, one principle has remained constant: The Science Center’s commitment to innovation, entrepreneurship and discovery.

Read the Message
Thanks to our strong foundation and a clear path forward, we are well positioned to build on these changes.”

Thanks to our strong foundation and a clear path forward, we are well positioned to build on these changes.”

Change Tomorrow

Discovery

Discovery Discovery Discovery Discovery Discovery Discovery Discovery
Treena Arinzeh, Ph.D.

Technology Commercialization: Trust the Process

The third time was a charm for Treena Arinzeh, Ph.D., and the Science Center’s QED Proof-of-Concept program. The New Jersey Institute of Technology researcher leveraged the mentoring and business advice she received through two rounds of the program, and in January 2018 she received $200,000 in funding to help bring her early-stage bone grafting technology to market.

Read the Story
This understanding of the target market, developing a strategy towards commercialization, and being able to identify and convey the need for the proposed technology were important aspects of what I learned.”

This understanding of the target market, developing a strategy towards commercialization, and being able to identify and convey the need for the proposed technology were important aspects of what I learned.”

– Treena Arinzeh, New Jersey Institute of Technology
$688M+
Leveraged by participants in the Science Center’s commercialization and accelerator programs to date.
23
Academic institutions participate in our science and technology programs.

Disruptive Discoveries

It’s no secret the companies at the Science Center are collectively shaping our future. Here’s a snapshot of a few: Port resident Group K Diagnostics is accelerating the pace at which blood and urine samples can be tested via a low-cost diagnostic system, providing results in 20 minutes. DHA participant PainQx is giving doctors a way to objectively measure pain by assessing neural activity from a patient’s brain. The output is a pain biomarker that can help inform the level of care a patient requires. Phase 1 Ventures, a cornerstone commercialization program, has committed close to $2M in early-stage companies since 2015. Recent beneficiary Talee Bio is focused on changing the course of cystic fibrosis and other genetic lung diseases by developing novel genetic treatments.

glow stick liquid being dropped into water

DHA Diversity

When the Science Center launched its Digital Health Accelerator in 2014, the goal was to help promising early-stage companies transition from R&D to customer acquisition and sales. $21M in revenue and $46M in investment later, we’re thrilled with the financial metrics from the first three cohorts of the DHA. We’re even more proud that 50% of active DHA companies are women-led businesses. The DHA is leveling the playing field for companies led by under-represented communities, while producing results competitive with the top-performing tech health accelerators in the U.S.

The funds and the resources offered by the DHA have helped catalyze RegDesk's growth. It is great to have a community of like-minded entrepreneurs focused on healthcare to exchange ideas and learn from each other's successes and failures."

The funds and the resources offered by the DHA have helped catalyze RegDesk's growth. It is great to have a community of like-minded entrepreneurs focused on healthcare to exchange ideas and learn from each other's successes and failures."

– Priya Bhutani, CEO, RegDesk
Change Tomorrow

Talent Pipeline

Talent Pipeline Talent Pipeline Talent Pipeline Talent Pipeline Talent Pipeline
closeup of the external limestone structure of coral

FirstHand Students Make Program History

FirstHand’s Project Inquiry students are changing tomorrow through the power of design. A group of 12 tenth graders from School of the Future were challenged to put their own spin on the brand identity of Evol Science, a biotech company located in the Science Center’s Port business incubator.

Read the Story

Lenfest Foundation Invests in Innovation Workforce

The Science Center received one of the largest private donations in its history in February 2018. The Lenfest Foundation awarded a $5 million grant to the Science Center, University City District (UCD) and Drexel University. The collaboration, anchored by UCD’s acclaimed job training program, the West Philadelphia Skills Initiative, will harness University City’s economic growth by connecting nearly 600 unemployed residents to family-sustaining careers over three years, generating $16 million in local wages. FirstHand’s Project Inquiry program will also expand, doubling the number of students served.

Lenfest’s investment in the Science Center is a down payment on the City’s future innovation workforce. We’re proud to support the Science Center’s work connecting high school students and underemployed West Philadelphians to careers at the thriving science and technology companies that are growing our economy.”

Lenfest’s investment in the Science Center is a down payment on the City’s future innovation workforce. We’re proud to support the Science Center’s work connecting high school students and underemployed West Philadelphians to careers at the thriving science and technology companies that are growing our economy.”

– Keith Leaphart, Lenfest Foundation Chair
When I Put On a Lab Coat…
Stepping foot into the FirstHand Lab, middle-school and high-school youth are transformed into scientists, engineers, artists and entrepreneurs. Through interdisciplinary project-based programs, FirstHand students create their own experiments and engineer prototypes, all while learning about the real-world applications of their work. Check out FirstHand’s new video to see what it’s like to participate in a FirstHand program.

ic@3401 Adds Character to its Repertoire

Angela Duckworth (pictured) and her team at Character Lab have joined ic@3401 as an anchor tenant. Character Lab was founded in 2013 by the Grit author, who is also the recipient of a MacArthur Foundation genius grant. Character Lab’s team of scientists, designers and educators is advancing the science and practice of character development in primary and secondary schools. They’re an impactful addition to the ic@3401 community which represents the largest group of funded early-stage tech companies in Philadelphia.

Angela Duckworth speaking at a podium
Change Tomorrow

Ecosystem

Ecosystem Ecosystem Ecosystem Ecosystem Ecosystem Ecosystem Ecosystem
macro photo of a leaf

Quorum Joins a Global Innovation Network

Quorum is playing a key role as the Science Center lays the groundwork for a partnership with CIC and Venture Café that will further catalyze and accelerate innovation and entrepreneurship in the region.

Read the Story
Free Venture Café powered by Quorum programming will give the innovation ecosystem an additional opportunity to convene, connect and spark new ideas.

Free Venture Café powered by Quorum programming will give the innovation ecosystem an additional opportunity to convene, connect and spark new ideas.

1,000
Quorum hit a major milestone in Fall 2017 when it hosted its 1,000th event.

Plug In to Quorum

72,000! That’s how many people Quorum has convened since opening in 2011. They’ve attended 1,000+ programs and events, consumed countless cups of coffee and made valuable connections to advance their ventures. As Quorum moves to 3675 Market, it will continue to support a community that’s buzzing with entrepreneurs, ideas and advice. Activity will scale as more people drop in to get work done, network with industry experts at signature programs, and host private events to bring people – and ideas – together. Quorum is the place where connection turns into innovation. All you have to do is plug in.

<strong>Look Up!</strong> Throngs of eclipse viewers convened on Innovation Plaza when the Science Center organized a solar eclipse viewing party in August 2017.
<strong>Getting to Know the Governor:</strong> Governor Tom Wolf held a round table discussion with a group of entrepreneurs and stakeholders in Quorum in August 2017.
<strong>Leveling the Playing Field:</strong> Philip Gaskin of the Ewing Marion Kauffman Foundation keynoted the ninth Annual RAIN Conference in July 2017 in Quorum. Conference goers explored diversity and access' role in building an inclusive entrepreneurial community.
<strong>Networking Al Fresco:</strong> RAIN conference participants continue the conversation about diversity and access in the PHS Pop Up Garden in July 2017.
<strong>The Power of the Network:</strong> Quorum was the site of some intense networking as the Science Center partnered with the STEM-UP Network to explore the Power of Networks for Female Entrepreneurs in December 2017.
Change Tomorrow

Breaking Boundaries

Breaking Boundaries Breaking Boundaries Breaking Boundaries Breaking Boundaries Breaking Boundaries
closeup of swirling paint as it dries

Celebrating Immigrant Entrepreneurs

America was built on the twin bedrocks of immigration and entrepreneurship. And when immigration and entrepreneurship intersect, magic happens. The Science Center honored an extraordinary group of immigrant entrepreneurs as we announced the newest class of the Innovators Walk of Fame at our Nucleus event in September 2017.

Read the Story
It was an incredible honor to be inducted into the Innovators Walk of Fame in 2017. To be included among such inspiring entrepreneurs who grew to call this great city Home like I have, and to put my life's work alongside theirs, was honestly humbling."

It was an incredible honor to be inducted into the Innovators Walk of Fame in 2017. To be included among such inspiring entrepreneurs who grew to call this great city home like I have, and to put my life's work alongside theirs, was honestly humbling."

—Chef Michael Solomonov

Acceleration for a Global Marketplace

In today’s marketplace, it’s critical that early-stage companies think globally from the start. Thanks to $500,000 awarded by the US Economic Development Administration in late 2017, the Science Center and the Welcoming Center for New Pennsylvanians are launching the Global Startup Accelerator to help Philadelphia-based companies effectively scale into global markets. The program will tap into the region’s business community and leverage the knowledge of successful immigrant professionals and their international networks to help local early-stage life sciences and technology startups as they plan for future expansions in foreign markets.

$50,000 Grant Supports New BioArt Residency

Thanks to a $50,000 grant from The John S. and James L. Knight Foundation, the Science Center is establishing a BioArt residency program fostering collaborations between artists and scientists. The residency will engage three artists over the course of one year. The first, Brooklyn-based interdisciplinary artist Laura Splan (whose work is pictured), began her residency in April 2018. Each artist will develop a creative research project in the lab of uCity Square-based biotechnology company Integral Molecular. Throughout the program, artists will host lectures and display their artwork at the Esther Klein Gallery.

46 sets of chromosomes along with a quote from Albert Einstein on Laura Splan's Subcutaneous series of hooped embroideries on facial peel

Penn and Wexford are Igniting Innovation

Our Ignite Innovation campaign got off to a roaring start in April 2018 with donations totaling $1.1 million from the University of Pennsylvania and Wexford Science + Technology! We are well on our way to reaching our $3 million goal. Funds raised will help us continue to inspire innovation through our current offerings while building a pipeline of programs that address the challenge of inclusion in tech-based economic development. We invite you to partner with us to equip scientists, artists, entrepreneurs, and students with the resources they need to change Greater Philadelphia — and the world.

Donate Now
“Lenfest’s investment in the Science Center is a down payment on the City’s future innovation workforce. We’re proud to support the Science Center’s work connecting high school students and underemployed West Philadelphians to careers at the thriving science and technology companies that are growing our economy.”

Supporting Quorum, the largest gathering space in Philadelphia dedicated to promoting collaboration and entrepreneurship in the region’s innovation ecosystem, is essential to the success and continued growth of uCity Square. We are delighted to make this philanthropic investment to the Science Center.”

– James Berens, Founder and CEO, Wexford Science + Technology
Change Tomorrow

Infrastructure

Infrastructure Infrastructure Infrastructure Infrastructure Infrastructure
street view of 3675 Market Street

Innovation Takes Flight at 3675 Market Street

As 3675 Market Street nears completion in summer 2018, we’re inspired by the transformations the new building will usher in. 3675 Market will fuel connectivity and discovery for our entire region. With street-level access and an expanded event space, Quorum will impact even more of the innovation ecosystem. Our FirstHand Lab will grow, introducing more students to STEM careers. And with anchor tenant and partner CIC managing turnkey lab and office space for startups and growing companies at 3675, the Science Center will strengthen its nationally recognized programs to accelerate innovation.

5 Blocks
Five blocks of new streets will connect uCity Square and the Science Center to the neighborhoods of Mantua, Powelton Village and West Powelton/Saunders Park.
<strong>Hardhat Tour:</strong> Getting ready for a hardhat tour of 3675 Market Street in November 2017.
<strong>Face Fragment:</strong> A freshly gilded nose and mouth shine again in front of the Monell Center on Market Street. The Percent for Art piece was refurbished by uCity Square resident Monell in advance of its 50th anniversary.
<strong>Meeting Ground:</strong> The first Science Center building, 3401 Market Street, is now home to tenants including Penn, Drexel and ic@3401.
<strong>Urban Art:</strong> Generative Luminence by Soo Sunny Park soars and sparkles above the 3737 Market Street lobby. The piece was commissioned by the Science Center and Wexford Science & Technology for the Philadelphia Redevelopment Authority's Percent for Art program.
<strong>Urban Oasis:</strong> The PHS Pop Up Garden at uCity Square brings a touch of green to the urban landscape.
345,000 SF
With 14 stories and 345,000 square feet of space, 3675 Market will be the tallest commercial life science/biotech/research building in Philadelphia.

$2.5M Grant Accelerates Development at uCity Square

Financial assistance provided by the Commonwealth of Pennsylvania’s Redevelopment Assistance Capital Program (RACP) is fueling development at uCity Square. The Science Center received a $2.5 million RACP grant to support the build-out of 3675 Market Street, including an expanded Quorum and FirstHand Lab, and the Science Center’s new corporate offices.